Lady Macduff first appearance was in act 4 scene 2 when she was talking to her cousin Ross

Lady Macduff first appearance was in act 4 scene 2 when she was talking to her cousin Ross. She expresses her sorrow whit her husband for fleeing the land whit out them as represented in the flowing quote: “Wisdom? To leave his wife, to leave his babes, His mansion and his titles in a place from whence himself does fly? He loves us not; He wants the natural touch; for the poor wren, the most diminutive of birds will fight, her young ones in her nest, against the owl. All is the fear, and nothing is the love, as little is the wisdom, where the flight so runs against all reason.” (Macbeth, Act 4, Scene 2, line 8-16)